Abstract Background Resistance of cholangiocarcinoma to chemotherapy is a major problem in cancer treatment.The mechanism of resistance is believed to involve phosphoinositide-3- kinase (PI3K)/Akt activation.Although the platinum-containing compound oxaliplatin has lorenametaute.com been extensively used in the treatment of several solid tumors, re
In the last two decades stalking phenomenon is recognized and actualized in the world in professional, scientific circles, in media and the everyday talk.Recently, stalking is identified as specific and complex problem studied separately from markbroyard.com domestic violence, workplace abuse, sexual harassment, threats, following, homicide, voyeur
We describe a 45-year-old married woman with sleepwalking, sleep-related eating disorder, and sleep-related smoking behavior, but without restless legs syndrome.The patient had a history of mild obstructive sleep apnea with an AHI of 12.6/hour with an oxygen saturation nadir of 95%, which resolved after bariatric surgery.Treatment with topiramate 1